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Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide

The TP53-induced glycolysis and apoptosis regulator (TIGAR) has been shown to decrease glycolysis, to activate the pentose phosphate pathway, and to provide protection against oxidative damage. Hypoxic regions are considered characteristic of glioblastoma and linked with resistance to current treatm...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Maurer, Gabriele D., Heller, Sonja, Wanka, Christina, Rieger, Johannes, Steinbach, Joachim P.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429390/
https://ncbi.nlm.nih.gov/pubmed/30823646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20051061
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