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Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide

The TP53-induced glycolysis and apoptosis regulator (TIGAR) has been shown to decrease glycolysis, to activate the pentose phosphate pathway, and to provide protection against oxidative damage. Hypoxic regions are considered characteristic of glioblastoma and linked with resistance to current treatm...

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Podrobná bibliografie
Vydáno v:Int J Mol Sci
Hlavní autoři: Maurer, Gabriele D., Heller, Sonja, Wanka, Christina, Rieger, Johannes, Steinbach, Joachim P.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429390/
https://ncbi.nlm.nih.gov/pubmed/30823646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20051061
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