Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide

The TP53-induced glycolysis and apoptosis regulator (TIGAR) has been shown to decrease glycolysis, to activate the pentose phosphate pathway, and to provide protection against oxidative damage. Hypoxic regions are considered characteristic of glioblastoma and linked with resistance to current treatm...

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Detalhes bibliográficos
Main Authors: Gabriele D. Maurer, Sonja Heller, Christina Wanka, Johannes Rieger, Joachim P. Steinbach
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-03-01
Colecção:International Journal of Molecular Sciences
Assuntos:
TP53-induced glycolysis and apoptosis regulator
glioma
hypoxia
irradiation
temozolomide
reactive oxygen species
hypoxia-inducible factor
Acesso em linha:http://www.mdpi.com/1422-0067/20/5/1061
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