Potent effects of dioscin against hepatocellular carcinoma through regulating TP53‐induced glycolysis and apoptosis regulator (TIGAR)‐mediated apoptosis, autophagy, and DNA damage

BACKGROUND AND PURPOSE: Dioscin shows potent effects against cancers. We aimed to elucidate its pharmacological effects and mechanisms of action on hepatocellular carcinoma (HCC) in vivo and in vitro. EXPERIMENTAL APPROACH: Effects of dioscin were investigated in SMMC7721 and HepG2 cells, diethylnit...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Mao, Zhang, Han, Xu, Chen, Dahong, Xu, Youwei, Xu, Lina, Yin, Lianhong, Sun, Huijun, Qi, Yan, Fang, Lingling, Liu, Kexin, Peng, Jinyong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433650/
https://ncbi.nlm.nih.gov/pubmed/30710454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14594
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