UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

The ATPase p97/Cdc48 promotes degradation of ubiquitin-conjugated proteins and its ability to bind substrates is mediated by cofactors containing ubiquitin-binding domains, such as NPL4/UFD1 or the yeast UBX domain protein Ubx2. Here, we employed 'network proteomics' to show that p97 assem...

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Bibliographic Details
Main Authors: Alexandru, Gabriela, Graumann, Johannes, Smith, Geoffrey T., Kolawa, Natalie J., Fang, Ruihua, Deshaies, Raymond J.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614663/
https://ncbi.nlm.nih.gov/pubmed/18775313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.06.048
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