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Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

Ubiquitin-dependent proteolysis can initiate at ribosomes for myriad reasons including misfolding of a nascent chain or stalling of the ribosome during translation of mRNA. Clearance of a stalled complex is required to recycle the ribosome for future use. Here we show that the ubiquitin (Ub) pathway...

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Detalhes bibliográficos
Main Authors: Verma, Rati, Oania, Robert S, Kolawa, Natalie J, Deshaies, Raymond J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552423/
https://ncbi.nlm.nih.gov/pubmed/23358411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00308
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