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Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome
Ubiquitin-dependent proteolysis can initiate at ribosomes for myriad reasons including misfolding of a nascent chain or stalling of the ribosome during translation of mRNA. Clearance of a stalled complex is required to recycle the ribosome for future use. Here we show that the ubiquitin (Ub) pathway...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3552423/ https://ncbi.nlm.nih.gov/pubmed/23358411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00308 |
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