A cis-Acting Diversification Activator Both Necessary and Sufficient for AID-Mediated Hypermutation

Hypermutation of the immunoglobulin (Ig) genes requires Activation Induced cytidine Deaminase (AID) and transcription, but it remains unclear why other transcribed genes of B cells do not mutate. We describe a reporter transgene crippled by hypermutation when inserted into or near the Ig light chain...

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Main Authors: Blagodatski, Artem, Batrak, Vera, Schmidl, Sabine, Schoetz, Ulrike, Caldwell, Randolph B., Arakawa, Hiroshi, Buerstedde, Jean-Marie
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2607555/
https://ncbi.nlm.nih.gov/pubmed/19132090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000332
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