Protein evolution by hypermutation and selection in the B cell line DT40

Genome-wide mutations and selection within a population are the basis of natural evolution. A similar process occurs during antibody affinity maturation when immunoglobulin genes are hypermutated and only those B cells which express antibodies of improved antigen-binding specificity are expanded. Pr...

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Bibliografiske detaljer
Main Authors: Arakawa, Hiroshi, Kudo, Hiroaki, Batrak, Vera, Caldwell, Randolph B., Rieger, Michael A., Ellwart, Joachim W., Buerstedde, Jean-Marie
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2008
Fag:
Methods Online
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248763/
https://ncbi.nlm.nih.gov/pubmed/18073192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm616
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