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Protein evolution by hypermutation and selection in the B cell line DT40
Genome-wide mutations and selection within a population are the basis of natural evolution. A similar process occurs during antibody affinity maturation when immunoglobulin genes are hypermutated and only those B cells which express antibodies of improved antigen-binding specificity are expanded. Pr...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2248763/ https://ncbi.nlm.nih.gov/pubmed/18073192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm616 |
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