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A cis-Acting Diversification Activator Both Necessary and Sufficient for AID-Mediated Hypermutation
Hypermutation of the immunoglobulin (Ig) genes requires Activation Induced cytidine Deaminase (AID) and transcription, but it remains unclear why other transcribed genes of B cells do not mutate. We describe a reporter transgene crippled by hypermutation when inserted into or near the Ig light chain...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2607555/ https://ncbi.nlm.nih.gov/pubmed/19132090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000332 |
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