A carregar...
A cis-Acting Diversification Activator Both Necessary and Sufficient for AID-Mediated Hypermutation
Hypermutation of the immunoglobulin (Ig) genes requires Activation Induced cytidine Deaminase (AID) and transcription, but it remains unclear why other transcribed genes of B cells do not mutate. We describe a reporter transgene crippled by hypermutation when inserted into or near the Ig light chain...
Na minha lista:
| Main Authors: | , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2607555/ https://ncbi.nlm.nih.gov/pubmed/19132090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000332 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|