Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats

OBJECTIVE—We examined in 20-week-old Zucker diabetic fatty (ZDF) rats whether restoration of hepatic glucokinase (GK) expression would alter hepatic glucose flux and improve hyperglycemia. RESEARCH DESIGN AND METHODS—ZDF rats were treated at various doses with an adenovirus that directs the expressi...

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Autori principali: Torres, Tracy P., Catlin, ReEtta L., Chan, Robert, Fujimoto, Yuka, Sasaki, Noriyasu, Printz, Richard L., Newgard, Christopher B., Shiota, Masakazu
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2009
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606896/
https://ncbi.nlm.nih.gov/pubmed/18952838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1119
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