Impact of a Glycogen Phosphorylase Inhibitor and Metformin on Basal and Glucagon-Stimulated Hepatic Glucose Flux in Conscious Dogs

The effects of a glycogen phosphorylase inhibitor (GPI) and metformin (MT) on hepatic glucose fluxes (μmol · kg(−1) · min(−1)) in the presence of basal and 4-fold basal levels of plasma glucagon were investigated in 18-h fasted conscious dogs. Compared with the vehicle treatment, GPI infusion suppre...

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Bibliografiske detaljer
Main Authors: Torres, Tracy P., Sasaki, Noriyasu, Donahue, E. Patrick, Lacy, Brooks, Printz, Richard L., Cherrington, Alan D., Treadway, Judith L., Shiota, Masakazu
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2011
Fag:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207486/
https://ncbi.nlm.nih.gov/pubmed/21363927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.177899
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