Cytoplasmic CUG RNA Foci Are Insufficient to Elicit Key DM1 Features

The genetic basis of myotonic dystrophy type I (DM1) is the expansion of a CTG tract located in the 3′ untranslated region of DMPK. Expression of mutant RNAs encoding expanded CUG repeats plays a central role in the development of cardiac disease in DM1. Expanded CUG tracts form both nuclear and cyt...

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Main Authors: Dansithong, Warunee, Wolf, Cordula M., Sarkar, Partha, Paul, Sharan, Chiang, Andy, Holt, Ian, Morris, Glenn E., Branco, Dorothy, Sherwood, Megan C., Comai, Lucio, Berul, Charles I., Reddy, Sita
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597774/
https://ncbi.nlm.nih.gov/pubmed/19092997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003968
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