RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP

We describe a new mechanism by which CTG tract expansion affects myotonic dystrophy (DM1). Changes to the levels of a panel of RNAs involved in muscle development and function that are downregulated in DM1 are due to aberrant localization of the transcription factor SHARP (SMART/HDAC1-associated rep...

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Detalhes bibliográficos
Main Authors: Dansithong, Warunee, Jog, Sonali P, Paul, Sharan, Mohammadzadeh, Robabeh, Tring, Stephanie, Kwok, Yukwah, Fry, Rebecca C, Marjoram, Paul, Comai, Lucio, Reddy, Sita
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128970/
https://ncbi.nlm.nih.gov/pubmed/21637295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.86
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