RNA Splicing Is Responsive to MBNL1 Dose

Myotonic dystrophy (DM1) is a highly variable, multi-system disorder resulting from the expansion of an untranslated CTG tract in DMPK. In DM1 expanded CUG repeat RNAs form hairpin secondary structures that bind and aberrantly sequester the RNA splice regulator, MBNL1. RNA splice defects resulting a...

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Main Authors: Jog, Sonali P., Paul, Sharan, Dansithong, Warunee, Tring, Stephanie, Comai, Lucio, Reddy, Sita
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499511/
https://ncbi.nlm.nih.gov/pubmed/23166594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048825
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