RNA Splicing Is Responsive to MBNL1 Dose

Myotonic dystrophy (DM1) is a highly variable, multi-system disorder resulting from the expansion of an untranslated CTG tract in DMPK. In DM1 expanded CUG repeat RNAs form hairpin secondary structures that bind and aberrantly sequester the RNA splice regulator, MBNL1. RNA splice defects resulting a...

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Detaylı Bibliyografya
Asıl Yazarlar: Jog, Sonali P., Paul, Sharan, Dansithong, Warunee, Tring, Stephanie, Comai, Lucio, Reddy, Sita
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499511/
https://ncbi.nlm.nih.gov/pubmed/23166594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048825
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