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SYNTHESIS OF BIPHENYLTRIENES AS PROBES FOR β-AMYLOID PLAQUES
We report a series of p-hydroxy, p-amino, p-monomethylamino and p-monofluoroethylamino substituted biphenyltrienes (14c, 14e, 14f and 14h), which displayed high binding affinities to β-amyloid (Aβ) plaques. In an in vitro binding assay using postmortem brain homogenates of Alzheimer’s patients and [...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597440/ https://ncbi.nlm.nih.gov/pubmed/16640346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm051020k |
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