Synthesis and evaluation of indolinyl- and indolylphenylacetylenes as PET imaging agents for β-amyloid plaques

Two new phenylacetylene derivatives, 5-((4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenyl)ethynyl)indoline 8 and 5-((4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenyl)ethynyl)-1H-indole 14, targeting β-amyloid (Aβ) plaques have been prepared. In vitro binding carried out in tissue homogenates prepared from p...

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Détails bibliographiques
Auteurs principaux: Qu, Wenchao, Choi, Seok-Rye, Hou, Catherine, Zhuang, Zhiping, Oya, Shunichi, Zhang, Wei, Kung, Mei-Ping, Manchandra, Rajesh, Skovronsky, Daniel M., Kung, Hank F.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577917/
https://ncbi.nlm.nih.gov/pubmed/18707879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.07.077
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