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F-18 Stilbenes As PET Imaging Agents For Detecting β-Amyloid Plaques In The Brain

Imaging agents targeting β,-amyloid (Aβ) may be useful for diagnosis and treatment of patients with Alzheimer’s disease (AD). Compounds 3e and 4e are fluorinated stilbene derivatives displaying high binding affinities for Aβ plaques in AD brain homogenates (K(i) = 15 ± 6 and 5.0 ± 1.2 nM, respective...

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Bibliographic Details
Main Authors: Zhang, Wei, Oya, Shunichi, Kung, Mei-Ping, Hou, Catherine, Maier, Donna L., Kung, Hank F.
Format: Artigo
Language:Inglês
Published: 2005
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593886/
https://ncbi.nlm.nih.gov/pubmed/16162001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050166g
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