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Suppression of Id2, a member of the inhibitor of differentiation family and a target of mutant p53, is required for mutant p53 gain of function
Over-expression of mutant p53 is a common theme in human tumors, suggesting a tumor-promoting gain of function for mutant p53. To elucidate whether and how mutant p53 acquires its gain of function, mutant p53 is inducibly knocked down in SW480 colon cancer cell line, which contains mutant p53(R273H/...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597213/ https://ncbi.nlm.nih.gov/pubmed/18701504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0810 |
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