Characterization of Functional Domains Necessary for Mutant p53 Gain of Function

Tumor cells, including SW480 carcinoma cells that carry a mutant p53, are addicted to the mutant for their survival and resistance to growth suppression by chemotherapeutic agents. Here, we investigated whether various classes of p53 mutants share a common property and functional domains necessary f...

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Bibliographic Details
Main Authors: Yan, Wensheng, Chen, Xinbin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863234/
https://ncbi.nlm.nih.gov/pubmed/20212049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.097253
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