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Cancer-derived p53 mutants suppress p53-target gene expression—potential mechanism for gain of function of mutant p53
Tumour-derived p53 mutants are thought to have acquired ‘gain-of-function’ properties that contribute to oncogenicity. We have tested the hypothesis that p53 mutants suppress p53-target gene expression, leading to enhanced cellular growth. Silencing of mutant p53 expression in several human cell lin...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1874625/ https://ncbi.nlm.nih.gov/pubmed/17344317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm099 |
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