Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8

Mutation of the p53 gene is the most common genetic alteration in human cancer and contributes to malignant process by enhancing transformed properties of cells and resistance to anticancer therapy. Mutant p53 is often highly expressed in tumor cells at least in part due to its increased half-life....

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Bibliographic Details
Main Authors: Yan, Wensheng, Liu, Shou, Xu, Enshun, Zhang, Jin, Zhang, Yanhong, Chen, Xiufang, Chen, Xinbin
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371110/
https://ncbi.nlm.nih.gov/pubmed/22391568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.81
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