Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo

Mutation of p53 occasionally results in a gain of function, which promotes tumor growth. We asked whether destabilizing the gain-of-function protein would kill tumor cells. Downregulation of the gene reduced cell proliferation in p53-mutant cells, but not in p53-null cells, indicating that the forme...

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Vydáno v:Oncotarget
Hlavní autoři: Jung, Chae Lim, Mun, Hyemin, Jo, Se-Young, Oh, Ju-Hee, Lee, ChuHee, Choi, Eun-Kyung, Jang, Se Jin, Suh, Young-Ah
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363612/
https://ncbi.nlm.nih.gov/pubmed/27765910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12758
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