Phospholipase A(2) reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

Neuronal expression of familial Alzheimer's disease (AD)-mutant human amyloid precursor protein (hAPP) and hAPP-derived amyloid-β (Aβ) peptides causes synaptic dysfunction, inflammation, and abnormal cerebrovascular tone in transgenic mice. Fatty acids may be involved in these processes, but th...

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Autors principals: Sanchez-Mejia, Rene O., Newman, John W., Toh, Sandy, Yu, Gui-Qiu, Zhou, Yungui, Halabisky, Brian, Cissé, Moustapha, Scearce-Levie, Kimberly, Cheng, Irene H., Gan, Li, Palop, Jorge J., Bonventre, Joseph V., Mucke, Lennart
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597064/
https://ncbi.nlm.nih.gov/pubmed/18931664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2213
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