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Curcumin inhibits Akt/mTOR signaling through protein phosphatase-dependent mechanism

Akt/mTOR signaling plays an important role in tumorigenesis and is dysregulated in many tumors, especially metastatic prostate cancers. Curcumin has been shown to effectively prevent or inhibit prostate cancer in vivo and inhibit Akt/mTOR signaling in vitro, but the mechanism(s) remains unclear. Her...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yu, Siwang, Shen, Guoxiang, Khor, Tin Oo, Kim, Jung-Hwan, Kong, Ah-Ng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596943/
https://ncbi.nlm.nih.gov/pubmed/18790744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-2400
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