A GRK5 Polymorphism that Inhibits β-Adrenergic Receptor Signaling is Protective in Heart Failure

β-adrenergic receptor (βAR) blockade is standard therapy for cardiac failure and ischemia. G-protein coupled receptor kinases (GRKs) desensitize βAR, suggesting that genetic GRK variants might modify outcomes in these syndromes. Re-sequencing of GRK2 and GRK5 revealed a non-synonymous polymorphism o...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Liggett, Stephen B., Cresci, Sharon, Kelly, Reagan J., Syed, Faisal M., Matkovich, Scot J., Hahn, Harvey S., Diwan, Abhinav, Martini, Jeffrey S., Sparks, Li, Parekh, Rohan R., Spertus, John A., Koch, Walter J., Kardia, Sharon L. R., Dorn, Gerald W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596476/
https://ncbi.nlm.nih.gov/pubmed/18425130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1750
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky