A GRK5 Polymorphism that Inhibits β-Adrenergic Receptor Signaling is Protective in Heart Failure

β-adrenergic receptor (βAR) blockade is standard therapy for cardiac failure and ischemia. G-protein coupled receptor kinases (GRKs) desensitize βAR, suggesting that genetic GRK variants might modify outcomes in these syndromes. Re-sequencing of GRK2 and GRK5 revealed a non-synonymous polymorphism o...

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Detalhes bibliográficos
Main Authors: Liggett, Stephen B., Cresci, Sharon, Kelly, Reagan J., Syed, Faisal M., Matkovich, Scot J., Hahn, Harvey S., Diwan, Abhinav, Martini, Jeffrey S., Sparks, Li, Parekh, Rohan R., Spertus, John A., Koch, Walter J., Kardia, Sharon L. R., Dorn, Gerald W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596476/
https://ncbi.nlm.nih.gov/pubmed/18425130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1750
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