A GRK5 Polymorphism that Inhibits β-Adrenergic Receptor Signaling is Protective in Heart Failure

β-adrenergic receptor (βAR) blockade is standard therapy for cardiac failure and ischemia. G-protein coupled receptor kinases (GRKs) desensitize βAR, suggesting that genetic GRK variants might modify outcomes in these syndromes. Re-sequencing of GRK2 and GRK5 revealed a non-synonymous polymorphism o...

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Bibliographic Details
Main Authors:	Liggett, Stephen B., Cresci, Sharon, Kelly, Reagan J., Syed, Faisal M., Matkovich, Scot J., Hahn, Harvey S., Diwan, Abhinav, Martini, Jeffrey S., Sparks, Li, Parekh, Rohan R., Spertus, John A., Koch, Walter J., Kardia, Sharon L. R., Dorn, Gerald W.
Format:	Artigo
Language:	Inglês
Published:	2008
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2596476/ https://ncbi.nlm.nih.gov/pubmed/18425130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1750
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A GRK5 Polymorphism that Inhibits β-Adrenergic Receptor Signaling is Protective in Heart Failure

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