Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels

The structure-activity relationships of organophosphorus (OP) and organosulfur compounds were examined in vitro and in vivo as inhibitors of mouse brain monoacylglycerol lipase (MAGL) hydrolysis of 2-arachidonoylglycerol (2-AG) and agonist binding at the CB1 receptor. Several compounds showed except...

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Autori principali: Nomura, Daniel K., Hudak, Carolyn S.S., Ward, Anna M., Burston, James J., Issa, Roger S., Fisher, Karl J., Abood, Mary E., Wiley, Jenny L., Lichtman, Aron H., Casida, John E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593629/
https://ncbi.nlm.nih.gov/pubmed/18752948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.08.007
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