CREB, ATF AND AP-1 TRANSCRIPTION FACTORS REGULATE IFN-γ SECRETION BY HUMAN T CELLS IN RESPONSE TO MYCOBACTERIAL ANTIGEN

IFN-γ production by T cells is pivotal for defense against many pathogens, and the proximal promoter of IFN-γ, −73 to −48 bp upstream of the transcription start site, is essential for its expression. However, transcriptional regulation mechanisms through this promoter in primary human cells remain u...

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Bibliographic Details
Main Authors: Samten, Buka, Townsend, James C., Weis, Steven E., Bhoumik, Anindita, Klucar, Peter, Shams, Homayoun, Barnes, Peter F.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587306/
https://ncbi.nlm.nih.gov/pubmed/18641343
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