Elevated Cyclic AMP Inhibits Mycobacterium tuberculosis-Stimulated T-cell IFN-γ Secretion Through Type I Protein Kinase A

Cyclic adenosine monophosphate (cAMP) is critical in immune regulation, and its role in tuberculosis infection remains unclear. We determined the levels of cAMP in peripheral blood mononuclear cells (PBMC) from tuberculosis patients and the mechanisms for cAMP suppression of IFN-γ production. PBMC f...

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Vydáno v:J Infect Dis
Hlavní autoři: Chung, Yoon-tae, Pasquinelli, Virginia, Jurado, Javier O, Wang, Xisheng, Yi, Na, Barnes, Peter F, Garcia, Veronica E, Samten, Buka
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946837/
https://ncbi.nlm.nih.gov/pubmed/29438524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy079
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