ESAT-6 Inhibits Production of IFN-γ by Mycobacterium tuberculosis-Responsive Human T Cells()

The Mycobacterium tuberculosis early secreted Ag of 6 kDa (ESAT-6) is a potent Ag for human T cells and is a putative vaccine candidate. However, ESAT-6 also contributes to virulence in animal models, mediates cellular cytolysis, and inhibits IL-12 production by mononuclear phagocytes. We evaluated...

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Publicado no:J Immunol
Main Authors: Wang, Xisheng, Barnes, Peter F., Dobos-Elder, Karen M., Townsend, James C., Chung, Yoon-tae, Shams, Homayoun, Weis, Stephen E., Samten, Buka
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488288/
https://ncbi.nlm.nih.gov/pubmed/19265145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803579
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