The Mycobacterium tuberculosis Early Secreted Antigenic Target of 6 kDa Inhibits T Cell Interferon-γ Production through the p38 Mitogen-activated Protein Kinase Pathway

We reported previously that the early secreted antigenic target of 6 kDa (ESAT-6) from Mycobacterium tuberculosis directly inhibits human T cell IFN-γ production and proliferation in response to stimulation with anti-CD3 and anti-CD28. To determine the mechanism of this effect, we treated T cells wi...

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Bibliographic Details
Main Authors: Peng, Hui, Wang, Xisheng, Barnes, Peter F., Tang, Hua, Townsend, James C., Samten, Buka
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129230/
https://ncbi.nlm.nih.gov/pubmed/21586573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.234062
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