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Proliferating cells express mRNAs with shortened 3′ UTRs and fewer microRNA target sites
mRNA stability, localization, and translation are largely determined by sequences in the 3′ untranslated region (UTR). Here, we describe a conserved increase in expression of mRNAs terminating at upstream polyadenylation sites (PAS) following activation of primary murine CD4(+) T lymphocytes. This p...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587246/ https://ncbi.nlm.nih.gov/pubmed/18566288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1155390 |
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