Proliferating cells express mRNAs with shortened 3′ UTRs and fewer microRNA target sites

mRNA stability, localization, and translation are largely determined by sequences in the 3′ untranslated region (UTR). Here, we describe a conserved increase in expression of mRNAs terminating at upstream polyadenylation sites (PAS) following activation of primary murine CD4(+) T lymphocytes. This p...

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Bibliographic Details
Main Authors: Sandberg, Rickard, Neilson, Joel R., Sarma, Arup, Sharp, Phillip A., Burge, Christopher B.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587246/
https://ncbi.nlm.nih.gov/pubmed/18566288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1155390
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