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Most mammalian mRNAs are conserved targets of microRNAs

MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-transcriptional repression. Many sites that match the miRNA seed (nucleotides 2–7), particularly those in 3′ untranslated regions (3′UTRs), are preferentially conserved. Here, we overhauled our tool for finding p...

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Autors principals: Friedman, Robin C., Farh, Kyle Kai-How, Burge, Christopher B., Bartel, David P.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612969/
https://ncbi.nlm.nih.gov/pubmed/18955434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.082701.108
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