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Proliferating cells express mRNAs with shortened 3′ UTRs and fewer microRNA target sites

mRNA stability, localization, and translation are largely determined by sequences in the 3′ untranslated region (UTR). Here, we describe a conserved increase in expression of mRNAs terminating at upstream polyadenylation sites (PAS) following activation of primary murine CD4(+) T lymphocytes. This p...

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Bibliografiska uppgifter
Huvudupphovsmän: Sandberg, Rickard, Neilson, Joel R., Sarma, Arup, Sharp, Phillip A., Burge, Christopher B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587246/
https://ncbi.nlm.nih.gov/pubmed/18566288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1155390
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