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MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

MicroRNAs are predicted to regulate thousands of mammalian genes, but relatively few targets have been experimentally validated and few microRNA loss-of-function phenotypes have been assigned. As an alternative to chemically modified antisense oligonucleotides, we developed microRNA inhibitors that...

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Détails bibliographiques
Auteurs principaux: Ebert, Margaret S, Neilson, Joel R, Sharp, Phillip A
Format: Artigo
Langue:Inglês
Publié: 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857099/
https://ncbi.nlm.nih.gov/pubmed/17694064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth1079
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