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Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR

In animals, microRNAs (miRNAs) bind to the 3′ UTRs of their target mRNAs and interfere with translation, although the exact mechanism of inhibition of protein synthesis remains unclear. Functional miRNA-binding sites in the coding regions or 5′ UTRs of endogenous mRNAs have not been identified. We s...

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Autors principals: Lytle, J. Robin, Yario, Therese A., Steitz, Joan A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887587/
https://ncbi.nlm.nih.gov/pubmed/17535905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703820104
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