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β-arrestin mediated localization of Smoothened to the primary cilium
β-arrestins have important roles in the regulation of seven-transmembrane receptors (7TMRs). Smoothened (Smo) is a 7TMR that mediates effects of Hedgehog on developmental processes and whose dysregulation may cause tumorigenesis. β-arrestins are required for endocytosis of Smo and signaling to Gli t...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587210/ https://ncbi.nlm.nih.gov/pubmed/18497258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1157983 |
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