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Modeling by Assembly and Molecular Dynamics Simulations of the Low Cu(2+) Occupancy Form of the Mammalian Prion Protein Octarepeat Region: Gaining Insight into Cu(2+)-Mediated β-Cleavage

The prion protein has garnered considerable interest because of its involvement in prion disease as well as its unresolved cellular function. The octarepeat region in the flexible N-domain is capable of binding copper through multiple coordination modes. Under conditions of low pH and low Cu(2+) con...

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Bibliografske podrobnosti
Main Authors: Pushie, M. Jake, Vogel, Hans J.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586590/
https://ncbi.nlm.nih.gov/pubmed/18790846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.139568
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