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Molecular Dynamics Simulations of Two Tandem Octarepeats from the Mammalian Prion Protein: Fully Cu(2+)-bound and Metal-Free Forms

Molecular dynamics simulations have been conducted on a model fragment (Ac-PHGGGWGQPHGGGW-NH(2)) of the prion protein octarepeat domain, both in the Cu(2+)-bound and metal-free forms. The copper-bound models are based on the consensus structure of the core Cu(2+)-binding site of an individual octare...

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Detaylı Bibliyografya
Asıl Yazarlar: Pushie, M. Jake, Vogel, Hans J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Biophysical Society 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084230/
https://ncbi.nlm.nih.gov/pubmed/17704169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.109512
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