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Combined EXAFS and DFT Structure Calculations Provide Structural Insights into the 1:1 Multi-Histidine Complexes of Cu(II), Cu(I) and Zn(II) with the Tandem Octarepeats of the Mammalian Prion Protein

The metal coordinating properties of the prion protein (PrP) have been the subject of intense focus and debate since the first reports of copper interaction with PrP just before the turn of the century. The picture of metal coordination to PrP has been improved and refined over the past decade, and...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Pushie, M. Jake, Nienaber, Kurt H., McDonald, Alex, Millhauser, Glenn L., George, Graham N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287235/
https://ncbi.nlm.nih.gov/pubmed/25042361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201304201
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