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Modeling by Assembly and Molecular Dynamics Simulations of the Low Cu(2+) Occupancy Form of the Mammalian Prion Protein Octarepeat Region: Gaining Insight into Cu(2+)-Mediated β-Cleavage
The prion protein has garnered considerable interest because of its involvement in prion disease as well as its unresolved cellular function. The octarepeat region in the flexible N-domain is capable of binding copper through multiple coordination modes. Under conditions of low pH and low Cu(2+) con...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586590/ https://ncbi.nlm.nih.gov/pubmed/18790846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.139568 |
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