High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

DNA encoding facilitates the construction and screening of large chemical libraries. Here, we describe general strategies for the stepwise coupling of coding DNA fragments to nascent organic molecules throughout individual reaction steps as well as the first implementation of high-throughput sequenc...

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Detaylı Bibliyografya
Asıl Yazarlar: Mannocci, Luca, Zhang, Yixin, Scheuermann, Jörg, Leimbacher, Markus, De Bellis, Gianluca, Rizzi, Ermanno, Dumelin, Christoph, Melkko, Samu, Neri, Dario
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Physical Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584757/
https://ncbi.nlm.nih.gov/pubmed/19001273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805130105
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