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High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries
DNA encoding facilitates the construction and screening of large chemical libraries. Here, we describe general strategies for the stepwise coupling of coding DNA fragments to nascent organic molecules throughout individual reaction steps as well as the first implementation of high-throughput sequenc...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2584757/ https://ncbi.nlm.nih.gov/pubmed/19001273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805130105 |
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