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Hit validation methodologies for ligands isolated from DNA-encoded chemical libraries
DNA-encoded chemical libraries (DECLs) are large collections of compounds linked to DNA fragments, serving as amplifiable barcodes, which can be screened on target proteins of interest. In typical DECL selections, preferential binders are identified by high-throughput DNA sequencing, comparing their...
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| Publicado no: | Chembiochem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5722192/ https://ncbi.nlm.nih.gov/pubmed/28067010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600637 |
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