High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

DNA encoding facilitates the construction and screening of large chemical libraries. Here, we describe general strategies for the stepwise coupling of coding DNA fragments to nascent organic molecules throughout individual reaction steps as well as the first implementation of high-throughput sequenc...

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Main Authors: Mannocci, Luca, Zhang, Yixin, Scheuermann, Jörg, Leimbacher, Markus, De Bellis, Gianluca, Rizzi, Ermanno, Dumelin, Christoph, Melkko, Samu, Neri, Dario
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
主題:
Physical Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584757/
https://ncbi.nlm.nih.gov/pubmed/19001273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805130105
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