High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

DNA encoding facilitates the construction and screening of large chemical libraries. Here, we describe general strategies for the stepwise coupling of coding DNA fragments to nascent organic molecules throughout individual reaction steps as well as the first implementation of high-throughput sequenc...

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Autors principals: Mannocci, Luca, Zhang, Yixin, Scheuermann, Jörg, Leimbacher, Markus, De Bellis, Gianluca, Rizzi, Ermanno, Dumelin, Christoph, Melkko, Samu, Neri, Dario
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Physical Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584757/
https://ncbi.nlm.nih.gov/pubmed/19001273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805130105
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