Dual Roles of Glycosyl Torsion Angle Conformation and Stereochemical Configuration in Butadiene Oxide-Derived N1 β-Hydroxyalkyl Deoxyinosine Adducts: A Structural Perspective

The solution structure of the N1-(1-hydroxy-3-buten-2(R)-yl)-2′-deoxyinosine adduct arising from the alkylation of adenine N1 by butadiene epoxide (BDO), followed by deamination to deoxyinosine, was determined, in the oligodeoxynucleotide d(CGGACXAGAAG)•d(CTTCTCGTCCG). This oligodeoxynucleotide cont...

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Detalhes bibliográficos
Principais autores: Merritt, W. Keither, Kowalczyk, Agnieszka, Scholdberg, Tandace A., Dean, Stephen M., Harris, Thomas M., Harris, Constance M., Lloyd, R. Stephen, Stone, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584607/
https://ncbi.nlm.nih.gov/pubmed/16022502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx050023x
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