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MUTAGENIC BYPASS OF THE BUTADIENE-DERIVED 2′-DEOXYURIDINE ADDUCTS BY POLYMERASES ETA AND ZETA
Butadiene is a ubiquitous environmental chemical carcinogen, that when activated to its monoepoxide intermediate can react with the N3 position of cytosine, resulting in two stereoisomeric adducted bases that rapidly deaminate to N3 2′-deoxyuridine lesions. We have previously shown that replication...
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| Main Authors: | , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2007
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2180188/ https://ncbi.nlm.nih.gov/pubmed/17586533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2007.05.003 |
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