DNA Polymerase Eta Participates in the Mutagenic Bypass of Adducts Induced by Benzo[a]pyrene Diol Epoxide in Mammalian Cells

Y-family DNA-polymerases have larger active sites that can accommodate bulky DNA adducts allowing them to bypass these lesions during replication. One member, polymerase eta (pol eta), is specialized for the bypass of UV-induced thymidine-thymidine dimers, correctly inserting two adenines. Loss of p...

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Bibliographic Details
Main Authors: Klarer, Alden C., Stallons, L. Jay, Burke, Tom J., Skaggs, Robert L., McGregor, W. Glenn
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380003/
https://ncbi.nlm.nih.gov/pubmed/22745795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039596
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