PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity

Poly(ADP-ribosyl)ation (PARylation) is a complex and reversible posttranslational modification catalyzed by poly(ADP-ribose)polymerases (PARPs), which orchestrates protein function and subcellular localization. The function of PARP1 in genotoxic stress response upon induction of oxidative DNA lesion...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Fischer, Jan M. F., Zubel, Tabea, Jander, Kirsten, Fix, Jelena, Trussina, Irmela R. E. A., Gebhard, Daniel, Bergemann, Jörg, Bürkle, Alexander, Mangerich, Aswin
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2017
Assuntos:
Genotoxicity and Carcinogenicity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866831/
https://ncbi.nlm.nih.gov/pubmed/29196784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2115-6
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